How about an SEC/Big 12 challenge that's played the second week of the season every year? Even numbered years all the SEC teams host, odd numbered years, the Big 12 hosts. Matchups would be determined based on standings from last year. Since the SEC has division, you'd have to use the eye test for a few teams. The one exception is the conference champs, and runner ups play each other. Next year would look something like this:
Alabama at Oklahoma
Florida at Iowa State
Texas A&M would play at Texas but since they have issues, Oklahoma State will be substituted here.
This forces Georgia to play at Texas
Auburn at West Virginia
Missouri at TCU
LSU at Kansas State
Ole Miss at Texas Tech
Kentucky at Baylor
Tennessee at Kansas
The bottom 4 teams just like in basketball won't play in this challenge. USC (I'm still a fan of you but wow you suck. Beamer ball hopefully changes this), Mississippi State, Arkansas, and Vandy would be left out.